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Neurotrope BioScience, (NASDAQ:NTRP), formed in 2012, is at the forefront of the biotech industry and is focused on developing new therapies with Bryostatin 1 for the treatment of neurodegenerative diseases and developmental disorders.
Our experience, capabilities, and passion for innovative and novel drug therapies have enabled us to build a development pipeline that includes various treatment approaches with Bryostatin 1 for serious and difficult-to-treat diseases such as Alzheimer’s dementia and the Orphan diseases, Fragile X Syndrome (FXS) and Niemann-Pick Type C (NPC).

Multi Modal Efficacy
Bryostatin-1 activates Synaptic Growth Factors – BDNF, NGF, IGF, others. It also activates all amyloid-β Degrading Enzymes (ECE, Neprilysin, IDE). Bryostatin also activates α-secretase, which reduces formation of neurotoxic amyloid-β formed by γ-secretase and BACE. ApoE3 induces PKCϵ; by activating PKCϵ, so there is an increase in BDNF expression. Bryostatin blocks ApoE4's reduction of BDNF via HDAC inhibition. Bryostatin normalizes GSK3-β, thereby inhibiting pathological Tau protein transformation into neurofibrillary tangles (NFTs).

Alzheimer’s disease Bryostatin was tested in a 148 moderate to severe Alzheimer's disease patient population across 26 sites in the U.S. First patients dosed January 2016 . Primary efficacy endpoint based on Severe Impairment Battery Scale (SIB). Entry criteria was based on the MMSE score. Please see the full data set by reviewing our press release dated July 19, 2017.

Fragile X Syndrome (FXS) is a devastating genetic disorder with a prevalence (existing cases) in the U.S. of about 135,000 persons. FXS shows a combination of the following signs in children and throughout life including developmental delays, intellectual and learning disabilities, anxiety, and autism spectrum disorders. In multiple FXS animal models it was shown that Bryostatin 1 improved memory and learning. Neurotrope is expanding on the BRNI preclinical data to show that Bryostatin 1 improves behavior in a collaboration with the FRAXA Research Foundation. Neurotrope BioScience plans to institute a Phase 2 clinical trial in FXS patients in 2018

Niemann Pick Type C is both a debilitating and lethal genetic disease occurring in all ethnic groups. Its prevalence is estimated to affect about 35,000 children per year. Neurotrope is working with world renowned experts at the Icahn School of Medicine, Mt. Sinai to develop its lead compound, bryostatin-1, as a potential treatment for the excessive accumulation of cholesterol and other lipids in the viscera and brain resulting in cell death and to neuologic symptoms, including difficulty in swallowing and speaking, loss of coordination, seizures, and progressive dementia. There is no FDA approved treatment for Niemann-Pick Type C.

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Alzeimer’s disease and Neurodegeneration Presentation

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Sachs Keynote 2016

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Sachs Keynote 2017

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