Neurotrope |
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WHO WE ARE

 

Neurotrope is a clinical-stage biotech company leveraging Bryostatin-1 and its analogues to discover and develop targeted therapeutics for neurodegenerative diseases and developmental disorders.

 

Our experience and passion for novel drug therapies have enabled us to develop a pipeline that includes various treatment approaches for serious and difficult-to-treat diseases such as Alzheimer’s Disease, Fragile X Syndrome and Niemann-Pick Type C.

SCIENCE

 

Neurotrope has targeted Bryostatin-1 due to its high potential and multi-modal efficacy: through protein kinase C (PKCϵ) activation, Bryostatin-1 stimulates synaptic growth factors, amyloid-β degrading enzymes, as well as prevents Tau transformation into neurofibrillary tangles.

 

Studies have demonstrated that PKCϵ plays a pivotal role in learning and memory. Bryostatin, a small molecule, penetrates the blood-brain barrier and activates PKCϵ, resulting in improved synaptic function, new synapse formation, repair of damaged synapses, and prevention of neuronal death. Neurotrope’s preclinical work demonstrates improved memory and learning in multiple Alzheimer’s mouse models and several other animal models.

ALZHEIMER’S DISEASE

Alzheimer’s disease is the most common form of dementia, accounting for 60%-80% of all cases. Neurotrope has conducted the first placebo-controlled, Phase 2 trial of a protein kinase C epsilon (PKCɛ) activator for the treatment of Alzheimer’s, which in preclinical studies induced the growth of new synapses and prevented neuronal death. Recent clinical trial data showed sustained increase in Severe Impairment Battery measures and improvement in cognition, suggesting the drug may treat the progression of AD, rather than just symptoms. A confirmatory trial will commence in 2018.

FRAGILE X SYNDROME

Fragile X syndrome is a genetic disorder that causes developmental delays, intellectual and learning disabilities, anxiety, and autism spectrum disorders. FXS affects 135,000 in the U.S. alone. Bryostatin-1 for Fragile X has been designated as an orphan drug, and in animal models, was shown to restore synaptic networks, rectify memory deficits, and reverse biochemical abnormalities. Neurotrope preclinical data, in a collaboration with the FRAXA Research Foundation, showed that Bryostatin-1 significantly improves autism spectrum abnormalities. Neurotrope plans to initiate clinical testing of FXS patients in 2018.

NIEMANN PICK TYPE C

Niemann Pick Type C is both a debilitating and lethal disease, affecting about 35,000 children per year. Neurotrope is working with world renowned experts at the Icahn School of Medicine, Mt. Sinai to develop its lead compound, Bryostatin-1, as a potential treatment for the excessive accumulation of cholesterol and other lipids in the viscera and brain resulting in cell death and to neuologic symptoms, including difficulty in swallowing and speaking, loss of coordination, seizures, and progressive dementia. There is no FDA approved treatment for Niemann-Pick Type C.

LINKS TO PUBLICATIONS
Key PublicationsDownload
PKC epsilon Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95 J Biol Chem. 5;291(32):16462-76, 2016 Abhik Sen, Jarin Hongpaisan, Desheng Wang, Thomas J. Nelson and Daniel L. Alkon
Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice. J. Pharmacol. Exp. Ther. 357: 300-310, 2016Miao-Kun Sun, Jarin Hongpaisan, and Daniel L. Alkon
ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation Neuroscience 35(19): 7538-7551; doi: 10.1523 /JNEUROSCI. 0260-15.2015 Abhik Sen, Thomas J. Nelson and Daniel L. Alkon
Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cε. J Biol Chem 287(19), 15947-15948, 2012. Sen A, Alkon DL, Nelson TJ
PKCε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice, Journal of Neuroscience, 31(2):630–643, 2011. Hongpaisan, J., Sun, MK, Alkon DL
Postischemic PKC activation rescues retrograde and anterograde long-term memory. (Proc Nat. Acad. Sci. USA) 106 (34): 14676–14680, 2009. Sun, MK, Hongpaisan, J, Alkon, DL
A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci USA 104 (49): 19571-19576, 2007. Hongpaisan J, and Alkon DL
Towards universal therapeutics for memory disorders. Trends in Pharmacological Sciences, June 2015, Vol. 36, No. 6. Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon
PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiology of Disease 41 (2011) 329–337. Ofer Zohar, Rotem Lavy, Xiaomei Zi, Thomas J. Nelson, Jarin Hongpaisan, Chaim G. Pick, D.L. Alkon

PIPELINE

 

Neurotrope is building a sustainable pipeline of treatments in major areas of unmet need.

“Neurotrope’s recent discoveries are some of the most promising new developments in Alzheimer’s research.”

 

–  George Perry, Ph.D., Professor of Neurobiology and Dean of the College of Sciences at The University of Texas at San Antonio

TEAM

 

Neurotrope is led by an experienced team with deep expertise in neurodegenerative disorders and successful track records in both drug discovery and development.

Charles Ryan, J.D., Ph.D.
Chief Executive Officer

Daniel Alkon, M.D.
President & Chief Science Officer

Robert Weinstein
Chief Financial Officer

Alan Tuchman, M.D.
Acting Chief Medical Officer

Elaine Grenier
Executive Director, Clinical Ops

Joshua Silverman

Chairman

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William Singer

Vice Chairman

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Charles Ryan, J.D., Ph.D.

Director & CEO

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James Gottlieb

Director

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Shana Phares

Director

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Bruce Bernstein

Director

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George Perry, Ph.D.

Director

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Martin R. Farlow

(Chairman) MS

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Paul Coleman, PhD

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Daniel F. Hanley Jr. MD

 

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Marwan Sabbagh, MD

 

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Lee Jen Wei, PhD

 

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CONTACT US

CORPORATE ADDRESS

New York Office

1185 Avenue of the Americas, 3rd Floor
New York, NY 10036
(973) 242-0005

Princeton Office

112 Nassau Street
Princeton, NJ 08540
(973) 500-6756

INVESTOR RELATIONS
Jeffrey Benison
Director of Communications
(212) 334-8709

jbenison@neurotrope.com

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